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There are two main types of transport systems which are used to transport solutes across a cell membrane: passive transport and active transport. Passive transport is where a protein in the membrane simply provides a 'hole' in the membrane, which allows the solute to flow freely in both directions. In this case, the flow of the solute is determined entirely by the concentration gradient across the membrane, and no energy is input to aid the movement (hence the term passive). Active transport is where the protein in the membrane actually binds to the solute, and conformational changes in the protein shape literally carry the solute across the membrane, then release it on the other side. This mechanism is designed for situations where movement of solutes against their concentration gradient is required, and requires the input of energy. This energy can come from one of a few places: * Primary active transport involves deriving the energy required to move the solute from the hydrolysis of ATP (Adenosine Triphosphate). In this case, the protein acting as the carrier is referred to as an ATPAse. * Secondary active transport involves deriving the energy from the movement of another solute across the membrane. This second solute will be flowing in the direction of its concentration gradient, so energy is released as it crosses the membrane. This allows it to drive the conformational changes in the protein that carry the solute across.

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