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To reveal the extent of domain-wide epigenetic features at imprinted gene clusters, we performed a high-resolution allele-specific chromatin analysis of over 100 megabases along the maternally or paternally duplicated distal chromosome 7 (Chr7) and Chr15 in mouse embryo fibroblasts (MEFs). We found that reciprocal allele-specific features are limited to imprinted genes and their differentially methylated regions (DMRs), whereas broad local enrichment of H3K27me3 (BLOC) is a domain-wide feature at imprinted clusters. We uncovered novel allele-specific features of BLOCs. A maternally biased BLOC was found along the H19-Igf2domain. A paternal allele-specific gap was found alongKcnq1ot1, interrupting a biallelic BLOC in the Kcnq1-Cdkn1c domain. We report novel allele-specific chromatin marks at the Peg13 and Slc38a4 DMRs, Cdkn1cupstream region, and Inpp5f_v2 DMR and paternal allele-specific CTCF binding at the Peg13 DMR. Additionally, we derived an imprinted gene predictor algorithm based on our allele-specific chromatin mapping data. The binary predictor H3K9ac and CTCF or H3K4me3 in one allele and H3K9me3 in the reciprocal allele, using a sliding-window approach, recognized with precision the parental allele specificity of known imprinted genes, H19, Igf2, Igf2as, Cdkn1c, Kcnq1ot1, andInpp5f_v2 on Chr7 and Peg13 and Slc38a4 on Chr15. Chromatin features, therefore, can unequivocally identify genes with imprinted expression.
Inilalarawan sa tunay na PIlipinong Dula ang mga pangarap ng bansa. Dito ipinapakita ang mga katutubong kultura, paniniwala at tradisyon. Ikinukuwento rin ang paghihirap at pagpupunyagi sa buhay ng mga katutubong Pilipino. Dito rin mamamalas ang iba't ibang anyo ng kanilang pamahalaan at uri ng lipunan. Samakatuwid, ang tunay a dulang Pilipino ay nagbibigay ng mas malawak na pang-unawa sa kulturang Pilipino at nagbibigay ng kasagutan sa mga pangangailangan ng mga Pilipino. Higit sa lahat, ito'y nagsisilbing gabay para sa kabutihan ng mga mamamayang Pilipino.
Ang kasaysayan ng Dulang Pilipino ay isinlang sa lipunan ng mga katutubong Pilipino bago pa dumating ang mga dayuhang mananakop. Ayon kay Casanova, ang mga katutubo'y likas na mahiligin sa mga awit, sayaw, at tula na siyang pinag-ugatan ng mga unang anyo ng dula. Ang mga unang awitin ay NASA anyo ngtula. Ang mga katutubo rin ay mayaman sa epikong bayan na kalimita'y isinasalaysay sa pamamagitan ng pag-awit.Ang mga awit, sayaw at ritwal ay karaniwang ginaganap para sa pagdiriwang ng kaarawan, binyag, pagtutuli, ligawan, kasalan, kamatayan, pakikipagdigmaan , kasawian, pananagumpay, pagtatanim, pag-aani, at pangingisda, atbp. Bago dumating ang mga katutubong Pilipino.
Ang tunay na drama ayon kay Sebastian ay nagsimula noong mga unang taon ng pangungupkop ng mga Amerikano. Idinagdag pa ni Tiongson na ang drama ay binubuo ng tanghalan, iba't ibang kasuotan, iskripto, "characterization", at "internal conflict". Ito an pangunahing sangkap ng tunay na drama ayon sa banyagang kahulugan. Sa kabilang dako, ayon sa mga librong kinunsulta ko, ang drama ay drama kahit wala ang mga sangkap na nabanggit. Ito ang dramang Pilipino. Ayon pa rink ay Tiongson. Memises ang pangunahing sangkap ng Dulang Pilipino. Memises ay ang pagbibigay buhay ng actor sa mga pang-araw-araw na pangyayari sa buhay ng mga Pilipino. Ito rin ang malaking pagkakaiba ng banayaga sa Pilipinong dula.
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What is the difference between recombinant and parental chromatids and how do they arise?
Parental chromatids are chromatids that have a combination of alleles identical to the parents and Recombinant chromatids are chromatids that have a mix of alleles from both parents.
What is a hybrid offspring?
ex: Aa,Bb, Cc, Dd, Ee, Ff, Gg, Hh, Ii, Jj, Kk, Ll, Mm, Nn, Oo, Pp, Qq, Rr, Ss, Tt, Uu, Vv, Ww, Xx, Yy, Zz.
What alleles do the f1 offspring have and why?
The alleles of the f1 offspring will depend on the alleles of the parents. In theory all of the alleles in the parental genotypes could be present in the f1 generation.To work out which combinations of alleles will be present in the f1 generation/the proportion with one allele etc. you would need to draw some kind of cross.AA x AaA AA AA AAa aA aASo the f1 offspring have both the A and a alleles, because the two alleles from each parent are separated into the gametesAA gives two gametes both with 'A' alleleAa gives on gamete with 'A' and one with 'a'
What type of alleles mask recessive alleles?
Dominant alleles :-)
What are the multiple forms of genes called?
Alleles are genes that exist in multiple forms.
What is the difference between recombinant and parental chromatids and how do they arise?
Parental chromatids are chromatids that have a combination of alleles identical to the parents and Recombinant chromatids are chromatids that have a mix of alleles from both parents.
How traits are inherited through alleles?
By sexual reproduction the parental alleles through gametes are inherited in the subsequent generation
What are the Chromosomes that have a mix of parental material alleles are called?
I really have no clue so why did you even come here?
What is the probability that a colorblind woman and a man with normal vision will have a colorblind daughter?
It all will depend on what kind of (recessive or dominant) alleles are responsible for the colorblind characteristic and what kind of alleles do the parental genes have.
What is a hybrid offspring?
ex: Aa,Bb, Cc, Dd, Ee, Ff, Gg, Hh, Ii, Jj, Kk, Ll, Mm, Nn, Oo, Pp, Qq, Rr, Ss, Tt, Uu, Vv, Ww, Xx, Yy, Zz.
What alleles do the f1 offspring have and why?
The alleles of the f1 offspring will depend on the alleles of the parents. In theory all of the alleles in the parental genotypes could be present in the f1 generation.To work out which combinations of alleles will be present in the f1 generation/the proportion with one allele etc. you would need to draw some kind of cross.AA x AaA AA AA AAa aA aASo the f1 offspring have both the A and a alleles, because the two alleles from each parent are separated into the gametesAA gives two gametes both with 'A' alleleAa gives on gamete with 'A' and one with 'a'
What type of alleles mask recessive alleles?
Dominant alleles :-)
What are the multiple forms of genes called?
Alleles are genes that exist in multiple forms.
What term describes a pair of alleles that are the same?
Alleles that are the same = homozygous Alleles that are different = heterozygous
Name two common uses for DNA testing?
DNA fingerprinting, and testing for alleles.
Two different forms of the same gene are called?
Alleles
When more than two different alleles control a trait?
The presence of more than two alleles that control a trait is called multiple allele. An example of this is the group gene of ABO blood that has three alleles.
