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One is the NaHCO3 system better known as sodium bicarbonate-carbonic acid system, the phospate system and protein system also help regulating the acid base balance in the body. But the only sistem that is medically relevant is the first one mentioned two others are H2CO3 and HCO3

There are three primary systems that regulate the H+ concentration in the body fluids to prevent acidosis or alkalosis: (1) the chemical acid-base buffer systems of the body fluids, which immediately combine with acid or base to prevent excessive changes in H+ concentration; (2) the respiratory center, which regulates the removal of CO2 (and, therefore, H2CO3) from the extracellular fluid; and (3) the kidneys, which can excrete either acid or alkaline urine, thereby readjusting the extracellular fluid H+ concentration toward normal during acidosis or alkalosis.

Chemical buffers of the body include the bicarbonate, phosphate, and protein buffer systems. Chemical buffers are single or paired sets (a weak acid and its salt) of molecules that act rapidly to resist excessive shifts in pH by releasing or binding H+.

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