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Three examples are:

- Familiarity tests whereby some of the subjects are deceased and little remains available. For instance: when we try to assess the probability of a living person being related to a historical figure.

- Criminal investigations, where little material evidence remains to work with.

- Archaeological or palaeontological investigations. For instance: recently several genome assays have been performed on remnant Neanderthal DNA. Necessarily, the material samples were few and small.

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