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Guanine to Cytosine in DNA Via a triple hydrogen bond for example NH2 donor group bonds to the =O acceptor group on G? Similarly, the two donor groups on G (NH and NH2) match the acceptor groups on C

The NH2 at the top of A would clash with the NH2 on C. You can't form an H-bond with two donor groups and no acceptor. Those two groups would actually get in each other's way, forcing the helix to distort. Also, A has no H-bond donors in the middle or at the bottom. So A and C can't pair.

T and C have a different problem. The top and middle groups of T could potentially h-bond with the complementary groups on C. But the helix would hold T and C too far apart. (The connection between each base and the backbone is the wavy line.) H-bonds can't form if the groups are to far apart from each other.

So this is why G and C have to be pared together

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14y ago

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