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There are several reasons you may have an elevated absolute white blood cell count. The first would be infection, infestation or allergic reaction - the number of white blood cells is increased because the immune system is responding to a perceived threat. The second would be cancer - the number of white blood cells is increased because the cancer is spewing out too many cells. A distant third would be dehydration, which would artificially increase the absolute number of white blood cells per mL simply because there is insufficient plasma to dissolve them in - this would be a mild elevation, if anything, and consistent across all types of white blood cells.

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