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The hormone produced by the para follicular cells of the thyroid

gland is calcitonin (CT).

CT can decrease the level of calcium in the blood by inhibiting

the action of osteoclasts, the cells that break down bone extracellular

matrix. The secretion of CT is controlled by a negative

feedback system.

When its blood level is high,calcitonin lowers the amount of

blood calcium and phosphates by inhibiting bone resorption

(breakdown of bone extracellular matrix) by osteoclasts and by

accelerating uptake of calcium and phosphates into bone extracellular

matrix.

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