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There are different signalling molecules and transcription factors which regulates the cell development and fate determination of the precursors via cell intrinsic and extrinsic mechanisms. In cell intrinsic or cell autonomous mechanism the molecules are secreted by the dividing precursors and which determines further proliferation and fate determination. In cell extrinsic mechanisms these molecules are secreted by the differentiated cells to regulate the differentiation of precursors non cell autonomously. This way the developing cells have a check on the precursors to develop the particular cell pool and organ type. The cell cycle regulators (FGF, Wnt and Notch etc) also play an important role in cell development. These molecules determines the exit of precursors from the cell cycle.

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15y ago

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