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1.Pituitary tumor leading to destuction of the gland--- this results in panhypopituitarism i.e. decreased secretion of all pituitary hormones.

2. thrombosis of pituitary bld. vessels also causes destruction of the gland again resulting in panhypopituitarism.

3. acidophilic tumours dev. in the gland which result in production of large amts. of GH (gigantism,acromegaly)

4. postpartum pituitary necrosis---sheehans syndrome.

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