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It depends on if you're referring to CG as an acronym or just a general reference to the genome. C, or cytosine, and G, or guanine, are two of the four bases that are the building blocks of DNA. An individual's genome, or his or her complete DNA code, is a series of these four bases. The other two are adenine (A) and thymidine (T).

Using "CG" in a different way, microarray technology is sometimes referred to as aCGH, which stands for "array comparative genomic hybridization". Microarray technology allows for the comparison of a test DNA sample against a partial control genome. This genome is represented by an array of probes, which are small pieces of DNA. How many probes one has in an array and which parts of the genome are represented customize the array to help a researcher/clinician interrogate the control sample for certain differences. They can be helpful in finding deleted or duplicated DNA material, for example.

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