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cGMP stands for current Good Manufacturing Practices. It is a set of guidelines and regulations established by regulatory agencies to ensure the quality and safety of pharmaceuticals, food, and other consumer products are consistently met during their manufacturing process. Adhering to cGMP helps to minimize risks and ensure products meet quality standards.

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What are the most common sources for cGMP?

The most common sources for cyclic guanosine monophosphate (cGMP) are the enzyme guanylate cyclase, which synthesizes cGMP from GTP, and phosphodiesterases, which degrade cGMP back into GMP. Nitric oxide (NO) is a key regulator of cGMP production, as it activates guanylate cyclase to increase cGMP levels. Additionally, certain drugs like sildenafil (Viagra) inhibit phosphodiesterases, leading to increased cGMP levels.


What pigment is synthesized from vitamin a?

cGMP


What does cGMP refer to in FDA regulations?

cGMP refers to "Current Good Manufacturing Practices". This practice is controlled by the Food and Drug Administration. They ensure that medications are safe for the public consumer.


Why written small c before cGMP?

Dear All just Logic when we start to write something we try scratching in small pits. same as in cGMP, GMP is old term as compared to cGMP, so SMALL "c" means new or current trends in OLD GMP. Second thing you can also write CGMP. Dr. P. Khemariya HEAD- Formulation Scientist


What is the 1st messenger of Cyclic AMP and cGMP?

The first messenger for cyclic adenosine monophosphate (cAMP) is a hormone or ligand that binds to a G protein-coupled receptor, leading to activation of adenylate cyclase and conversion of ATP to cAMP. For cyclic guanosine monophosphate (cGMP), the first messenger is typically nitric oxide (NO) which activates guanylyl cyclase leading to the production of cGMP from GTP.


How does Viagra work at a cellular level?

Viagra inhibits the enzyme that inhibits the production of cGMP. The purpose of cGMP is to activate Protein Kinase G which triggers muscle relaxation through the activation of phosphatase (an enzyme which removes a phosphate from smooth muscle myosin thus inhibiting cross bridges from being formed) and thus contraction is not permitted to happen. Basically through the use of Viagra cGMP can be active and this triggers a chain of events that allows the veins in the penis to dilate and thus an erection can occur.


What is a local regulator responsible for activating an enzyme that relaxes smooth muscle cells?

Nitric oxide is a local regulator responsible for activating an enzyme called guanylate cyclase, which then increases the levels of cyclic guanosine monophosphate (cGMP). cGMP leads to the relaxation of smooth muscle cells, thereby promoting vasodilation and increasing blood flow.


Why are sop's needed in a cgmp or gmp?

Standard operating procedures (SOPs) are needed in a CGMP or GMP environment to ensure consistency and quality of processes. They provide detailed instructions on how tasks should be performed, ensuring that all employees follow the same procedures and maintain quality standards. SOPs also help in reducing errors, fostering compliance with regulations, and facilitating training.


What has the author Eleni Angelidou written?

Eleni Angelidou has written: 'The nitric oxide-cGMP system in the human pregnant myometrial cells and its regulation by CRH'


Difference between GMP and cGMP?

There is no difference. the 'c' stands for current, so that whenever the law is added to or ammended, it becomes the current GMP, but no major changes have taken place since it's inception. These 2 terms can be used interchangeably. - is that a word?


What ionic and electrical events occur in the photoreceptors rods when it is dark?

In the dark, photoreceptor rods are depolarized due to a continuous influx of sodium ions through cGMP-gated channels, maintaining a steady release of glutamate neurotransmitter. This constant release of glutamate signals the dark adaptation state of the photoreceptor.


What substances are known as intracellular messengers in plants?

In plants, cyclic adenosine monophosphate (cAMP), cyclic guanosine monophosphate (cGMP), calcium ions, and reactive oxygen species (ROS) are known as intracellular messengers. They play essential roles in signaling pathways that regulate important processes such as growth, development, and response to environmental stimuli.