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The late prophase is one of the stages in mitosis and during this stage there is a break up of the nuclear envelope and the microtubules that the spindle fibers are made up of called the polar fibers reach from the pole to the equator of each cell. Specialized regions that are in the centromeres of chromosomes called Kinetochores attach to kinetochore fibers which are a type of microtubules. The spindle polar fibers connect the polar fibers to the kinetochores through their interaction with the kinetochore fibers and the chromosomes start to migrate towards the center of the cell.

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