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When a cell dies due to its age it often undergoes self-death, called apoptosis. Apoptosis is a form of controlled cell death where the cell breaks off into small pieces called apoptotic bodies. These bodies are then ingested by macrophages(or microglia in the brain, sometimes referred to as the brain macrophage). Once phagocytized into a phagosome within the macrophage, a lysosome will join the phagosome forming a phagolysosome. Within the phagolysosome the pH drops to around 3 and the enzymes become activated and digest the apoptotic body and recycle its nutrients. Any non-digestable material is stored in the macrophage and is often called lipofuschin.

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