What is Gilbert's disease?

Answer 1

Gilbert's syndrome, pronounced /ʒilˈbeɹ/ (jheel-BAYR), often shortened to GS, also called Gilbert-Meulengracht syndrome, is the most common hereditary cause of increased bilirubin and is found in up to 5% of the population (though some gastroenterologists maintain that it is closer to 10%). It has an autosomal recessive pattern of inheritance. The main symptom is otherwise harmless jaundice, which does not require treatment, caused by elevated levels of unconjugated bilirubin in the bloodstream (hyperbilirubinemia).

The cause of this hyperbilirubinemia is the reduced activity of the enzyme glucuronyltransferase, which conjugates bilirubin and some other lipophilic molecules. Conjugation renders the bilirubin water-soluble, after which it is excreted in bile into the duodenum. (wikipedia)

Answer 2

Gilbert's disease, also known as Gilbert's syndrome, is a common benign liver condition where there is a mild increase in the bilirubin levels in the blood. This increase is due to a deficiency of an enzyme that helps process bilirubin in the liver. People with Gilbert's disease may experience occasional jaundice, but typically do not require treatment.