synaptic/graded potential
Action Potential
The membrane or resting potential is the difference in voltage within and outside the cell when that cell is at rest. In a typical neuron it is usually around -65mV, meaning the neuron is negatively charged relative to the extracellular space. This potential is due to various ions and the permeability of the neuronal membrane. When a neuron gets a signal from another neuron, this causes the concentration of various ions to change (some flow in, others out of, the cell). In some cases, the signal causes positive ions to flow into the cell, making the membrane potential less negative. Once it reaches a threshold, usually around -55mV, the cell "fires" or makes an action potential, which is when the membrane potential temporarily shoots up to around +40mV. This signal propagates down the length of the neuron and then passes that message on to other cells.
action potential has a threshold stimulus and depolarization is just change in membrae potential where inside becomes for positive relative to outside. The AP has the ability to actually transmit info over long distance in axons once threshhold stimulus/depolarization is reached
Membrane potential - a nerve cell set and ready to fire;"The wave of reverse polarity" i.e. sodium versus potassium trans-cell-membrane ion passaging - a nerve cell firing; andRecharge period - the regeneration time.
Hyperkalemia is an increase in extracellular K. Driving force of an ion depends on two factors, voltage and concentration gradient. For K voltage gradient is pushing K into the cell but the concentration gradient is driving K out of the cell. However, the total driving force for K is out of the cell because the concentration gradient is that strong. When there is an increase in K on the outside, the driving force for K decreases.The equilibrium potential for K is -95mV. This means if K was freely permeable to the cell's membrane, it would reach equilibrium at -95mV. Another way to look at this is that efflux of K is the same as influx of K and the cell's new resting membrane potential would increase from a normal value of -70mV to -95mV. Note that I said it would increase even though the value became more negative. This is because the change in membrane potential has increased.Since the driving force of K has decreased, the equilibrium potential has also decreased. From a value of -95mV it is decreased to let's just say -80mV. Since a normal resting membrane potential is regularly -70mV, the decrease in equilibrium potential of K has decreased this resting membrane potential to say -60mV now. This is a depolarization of the cell.If this process happens quickly, it will depolarize the cell to the threshold value and you will have an action potential. However, if the hyperkalemia is severe, the cell will stay depolarized because the K equilibrium has decreased to a point where the cell cannot hyperpolarize back to threshold or resting membrane potential.If this process happens slowly, the inactivation gates of the sodium voltage-gated channels will automatically shut and the cell cannot depolarize even if it reaches threshold values. It must hyperpolarize back to resting membrane potential and the inactivation gates of the sodium voltage-gated channel will reopen.
Local responce is a small change in membrane potential caused by a subthreshold stimulus.
depolarization
despolarization
action potential
Action potential
An ion channel.
Opening or closing of ion channels at one point in the membrane produces a local change in the membrane potential, which causes electric current to flow rapidly to other points in the membrane.
recruitement
Action Potential
ions
it is patch lamp
voltage-gated ion channels