What is autosomal dominant?

Answer 1

In genetics, autosomal dominance means that an individual only needs to inherit one allele for a trait in order for that trait to be expressed. An individual must inherit a recessive trait from both parents in order for a recessive trait to be expressed.

Answer 2

These websites will probably explain it better then I can:

http://www.britannica.com/EBchecked/topic/228874/human-genetic-disease/242824/Autosomal-dominant-inheritance
http://www.wrongdiagnosis.com/genetics/dominant.htm
http://www.gig.org.uk/images/gen-dominant.gif

Answer 3

Autosomal dominant inheritance requires that only one copy of a gene pair be defective in order to develop the disorder. Each offspring of a parent with an autosomal dominant disorder has a 50% risk of inheriting the gene

Answer 4

Definition

Autosomal dominant is one of several ways that a trait or disorder can be passed down through families.

If a disease is autosomal dominant, it means you only need to get the abnormal gene from one parent in order for you to inherit the disease. One of the parents may often have the disease.

Alternative Names

Inheritance - autosomal dominant; Genetics - autosomal dominant

Information

Inheriting a disease, condition, or trait depends on the type of chromosome affected (autosomal or sex chromosome). It also depends on whether the trait is dominant or recessive.

A single, abnormal gene on one of the first 22 nonsex chromosomes from either parent can cause an autosomal disorder.

Dominant inheritance means an abnormal gene from one parent is capable of causing disease, even though the matching gene from the other parent is normal. The abnormal gene "dominates" the pair of genes. If just one parent has a dominant gene defect, each child has a 50% chance of inheriting the disorder.

For example, if four children are born to a couple and one parent has an abnormal gene for a dominant disease, statistically two children will inherit the abnormal gene and two children will not. Children who do not inherit the abnormal gene will not develop or pass on the disease.

If someone has an abnormal gene that is inherited in an autosomal dominant manner, then the parents should also be tested for the abnormal gene.

Examples of autosomal dominant disorders include Huntington's disease and neurofibromatosis-1.

See also:

• Autosomal recessive
• Genetic counseling and prenatal diagnosis
• Heredity and disease
• Sex-linked dominant
• Sex-linked recessive

References

Korf BR. Principles of Genetics. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 37.

Answer 5

Definition

Autosomal dominant is one of several ways that a trait or disorder can be passed down through families.

If a disease is autosomal dominant, it means you only need to get the abnormal gene from one parent in order for you to inherit the disease. One of the parents may often have the disease.

Alternative Names

Inheritance - autosomal dominant; Genetics - autosomal dominant

Information

Inheriting a disease, condition, or trait depends on the type of chromosome affected (autosomal or sex chromosome). It also depends on whether the trait is dominant or recessive.

A single, abnormal gene on one of the first 22 nonsex chromosomes from either parent can cause an autosomal disorder.

Dominant inheritance means an abnormal gene from one parent is capable of causing disease, even though the matching gene from the other parent is normal. The abnormal gene "dominates" the pair of genes. If just one parent has a dominant gene defect, each child has a 50% chance of inheriting the disorder.

For example, if four children are born to a couple and one parent has an abnormal gene for a dominant disease, statistically two children will inherit the abnormal gene and two children will not. Children who do not inherit the abnormal gene will not develop or pass on the disease.

If someone has an abnormal gene that is inherited in an autosomal dominant manner, then the parents should also be tested for the abnormal gene.

Examples of autosomal dominant disorders include Huntington's disease and neurofibromatosis-1.

See also:

• Autosomal recessive
• Genetic counseling and prenatal diagnosis
• Heredity and disease
• Sex-linked dominant
• Sex-linked recessive

References

Korf BR. Principles of Genetics. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 37.

Reviewed By

Review Date: 04/26/2010

Neil K. Kaneshiro, MD, MHA, Clinical Assistant Professor of Pediatrics, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

Answer 6

Two copies of an altered gene located on one of the autosomes must be present for an individual to be affected with the trait or condition determined by that gene.

Answer 7

it could be the sickle cells that bring the chromosomal