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The growth of microorganisms reproducing by binary fission can be plotted as the logarithm of the number of viable cells versus the incubation time. The resulting curve has four distinct phases and its mathamatical expression are called bacterial or microbial kinetics. Lag Phase When microorganisms are introduced into fresh culture medium, usually no immediate increase in cell number occurs, and therefore this period is called the lag phase.Exponential Phase During the exponential or log phase, microorganisms are growing and dividing at the maximal rate possible given their genetic potential, the nature of the medium, and the conditions under which they are growing. Stationary Phase Eventually population growth ceases and the growth curve becomes horizontal. This stationary phase usually is attained by bacteria at a population level of around 109 cells per ml. Death Phase Detrimental environmental changes like nutrient deprivation and the buildup of toxic wastes lead to the decline in the number of viable cells characteristic of the death phase. The death of a microbial population, like its growth during the exponential phase, is usually logarithmic During the exponential phase each microorganism is dividing at constant rate. Thus the population will double in during the specific length of time called the generation time or doubling time These observations can be expressed as equations for thegeneration time. Let No the initial population number Nt the population at time t n the number of generations in time t Then Nt = No multiply 2n

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What is the impact of an uncompetitive inhibitor on the values of Km and Vmax in enzyme kinetics?

An uncompetitive inhibitor decreases both the Km and Vmax values in enzyme kinetics.


What are the characteristics and implications of zero-order kinetics in drugs?

Zero-order kinetics in drugs refers to a constant rate of drug elimination regardless of the drug concentration in the body. This means that the drug is eliminated at a consistent rate over time. The implications of zero-order kinetics include a potential risk of drug accumulation in the body, leading to toxicity if the drug is not cleared efficiently. Monitoring drug levels and adjusting dosages accordingly is important when dealing with drugs that exhibit zero-order kinetics.


How does the uncompetitive inhibitor affect both the Km and Vmax values in enzyme kinetics?

An uncompetitive inhibitor affects both the Km and Vmax values in enzyme kinetics by decreasing the apparent Km value and reducing the Vmax value.


What is the significance of the parameter kcat in enzyme kinetics?

The parameter kcat in enzyme kinetics represents the turnover number, which is the rate at which an enzyme can convert substrate molecules into product molecules. It is a crucial factor in determining the efficiency of an enzyme and its catalytic activity.


How does uncompetitive inhibition affect both the Km and Vmax values in enzyme kinetics?

Uncompetitive inhibition affects both the Km and Vmax values in enzyme kinetics by decreasing the apparent Km value without changing the Vmax value.

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Where can you study human kinetics in southafrica?

Rhodes University offers a Bachlors Degree in Human Kinetics & Ergonomics.


I have a question About Kinetics?

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Where can one learn more about underwater kinetics?

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What topics are studied in kinetics?

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