What is bone metastasis?

Answer 1

Bone metastasis (plural; metastases) is the formation of cancerous cells inside bone. Bone metastases are usually caused by secondary metastases. It is a complex system that the cells undergo to inhabit the bone:

Cancerous cells undergo loss of intracellular cohesion, basically they lose the ability the stick together and also generate their own blood supply. Cancer cells then need to enter the blood system and survive. they attach themselves to blood cells and platelets and regain the ability of intracellular cohesion. when they reach the destination, they escape the blood supply; this process is called extravasion (the forcing of fluid out of a vessel) in this case out of the vein's, and into the target organ (in this case bone - intravasion). They then must evade capture by the immune system. They do this by sending out biological signals to prevent the immune system from fighting the cells. they then begin the process of doubling again and again.

To understand the biological effects on the bone look at coupled remodelling, which is a process run in equilibrium of normal bone oblation and remodelling until the bone metastases interfere with this process.

Answer 2

Bone metastasis is when cancer cells spread from their original site to the bones, where they can form new tumors. This can weaken the bones, leading to pain, fractures, and other complications. Bone metastasis is often treated with a combination of therapies to help manage symptoms and slow the progression of the disease.