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In my studies I have not thus far seen any instances in which sister chromatids did not separate in Anaphase, but there are instances where chromatids do not evenly cleave from one another and there is more genetic material in one gamete than another of the gametes, and the other two are "normal". I will illustrate this mathematically : N+1(24) , N-1(22), N(23), N(23).

This uneven split is called non-disjunction which can happen in Anaphase 1 or 2 in the gamete producing cell division known as Meiosis

One may familiar to one of the consequences of non-disjunction if he/she had heard of Down syndrome. Individuals with DS have 47 chromosomes. This is a condition called Trisomy where the 21st pair of sex determining X chromosomes has an extra X.

However, in many cases non-disjuction may have zero effect on individual. It is completley dependent on what pair of chromosomes has an extra, or one less chromosome that determines the outcome of the cells development.

I hope that helps somewhat.

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15y ago

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