Massive fatigue can be a sign of a serious illness. It can also be a sign that your adrenal glands are not working. It is important to go to your doctor and be tested to see what is wrong.
fatigue
The organelle that would cause fatigue is called the mitochondria. However, it will only cause fatigue if there's a defect in it.
It is not currently known what causes Chronic Fatigue syndrome. It is a syndrome that typically starts with flue like symptoms, and involves fatigue that is not significantly relieved by resting.
Massive weight
Symptom. A symptom is a subjective manifestation of a disease and it is expressed by the patient. A sign is an objective manifestation and it is seen by the clinician.
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The most common is fatigue, followed by muscle weakness or pain.