What is pseudopseudohypoparathyroid?

Answer 1

Pseudo means -like or similar.

The best way to understand this is to break it down.

Hypoparathyroid is an underactive parathyroid gland, so too little parathyroid hormone is released into the blood - this causes low calcium levels in the blood.

Pseudo-hypoparathyroid is like hypoparathyroid but instead of lack of parathyroid hormone causing the low calcium levels, it is resistance to the hormone at the receptor levels - hence it is pseudo- because it is like hypoparathyroid but the parathyroid hormone level is actually normal. It is associated with other abnormalities like short stature and short metacarpals (hand bones).

Pseudo-pseudo-hypoparathyroid has nothing to do with calcium, but it is "-like" pseudohypoparathyroid in terms of bone abnormalities.

Hope that helps.

Answer 2

It's a genetic disorder that closely simulates the symptoms, but not the consequences, of pseudohypoparathyroidism. Therefore, it has zero to mild manifestations of either hypoparathyroidism or tetanic convulsions.

Answer 3

Pseudopseudohypoparathyroidism is a rare genetic disorder characterized by physical features of Albright's hereditary osteodystrophy but without abnormal levels of calcium and phosphorus in the blood. It is caused by a mutation in the GNAS gene and can affect bone development and growth. Treatment is usually focused on managing symptoms and complications.