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NRBCs (nucleated red blood cells) are immature red blood cells that still contain a nucleus, typically seen in the blood of infants or in certain medical conditions. Reticulocytes are also immature red blood cells, but they have lost their nucleus. Reticulocytes are released from the bone marrow into the bloodstream to eventually mature into erythrocytes (mature red blood cells).

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What effect will NRBCs in the peripheral blood have on cbc report?

NRBCs are found in PBF in hemolytic anaemia. however it can be seen normally in neonates blood film.


Can EDTA degenerate nRBC?

Yes, EDTA can lead to degeneration of nucleated red blood cells (nRBCs) in a blood sample. EDTA acts as an anticoagulant by binding to calcium ions, which can cause nRBCs to swell, rupture, and lose their distinct morphology. This degeneration can make it challenging to accurately identify nRBCs in a blood smear.


What is nucleated rbc on a blood test?

Nucleated red blood cells (nRBCs) are immature red blood cells that still contain a nucleus and are typically found in the bone marrow. Their presence in peripheral blood is usually an indicator of a pathological condition, such as severe anemia, bone marrow stress, or certain diseases like thalassemia or leukemia. In healthy adults, nRBCs are rarely seen in circulation, but they can appear in newborns or in response to stress or injury in older individuals. The detection of nRBCs can provide important information about a person's hematological status and overall health.


Why is your nrbc elevated?

Elevated numbers of nucleated red blood cells (NRBCs) can indicate several underlying conditions. Common causes include severe hypoxia, bone marrow disorders, or stress responses to acute illness or trauma. NRBCs can also be present in newborns due to immature bone marrow function or in cases of hemolytic anemia. A thorough evaluation is necessary to determine the specific cause of the elevation.


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