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Mesosomes are infoldings of the plasma membrane in bacterial cells that participate in cell division, DNA replication, and cell wall synthesis. Episomes, on the other hand, are extrachromosomal genetic elements that can exist either autonomously as plasmids or integrate into the host cell genome. Episomes can replicate independently or be passed on to daughter cells during cell division.

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What is the difference between plasmid and episomes?

Plasmid DNA is an extra-chromosomal DNA molecule, it cannot link up with chromosomal DNA, and it contains the genetic informations that are necessary for its own replication. Episomes is any kind of extra-chromosomal DNA that can link up with chromosomal DNA. That is the main difference between them two. Episomes are usually larger than other extra-chromosomal DNA. An example of episome are the viruses, because they intergrate their genetic material into the host's chromosomal DNA.The only difference between the plasmid and the episome is the integration i-e plasmid can not integrate while episome can integrate into the genome.


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