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A unicellular organism and a multicellular organism are different because, those that are unicellular consist of only a single cell. Those cells are very simple because they lack a nuclei and their DNA is not separated from the rest of the cell . Any injury or death of cell in unicellular organism leads to death's. life span is short and theirs cell is comparatively large.Multicellular organisms on the other hand, are made of many cells and are major complex. Their cells do have a nuclei and have their DNA separated from the rest of the cell.Theirs life span is long. They have better adaptability for survival.theirs cell size is smaller .

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