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Pyruvate is formed from glucose during glycolysis. Should the conditions be aerobic, pyruvate will be converted into Acetyl Coenzyme A (CoA) with the help of an enzyme called "pyruvate dehydrogenase."

Bi-products of this reaction include CO2 and NADH This occurs in the matrix of the mitochondria. Acetyl CoA will then continue into the Krebs cycle/citric acid cycle. After this, the products of the cycle (NADH and FADH2) will be involved in oxidative phosphorylation and the electron transport chain where large amounts of ATP will be produced. This occurs in the inner layer of the mitochondria.

Should there be anaerobic conditions, then animals can convert pyruvate into lactate. Or, in plants; pyruvate is converted into ethanal and then into ethanol in a process called fermentation.

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What is the exact location of pyruvate oxidation in the mitochondrion?

Pyruvate oxidation takes place in the mitochondrial matrix. Here, pyruvate is converted into acetyl-CoA by the pyruvate dehydrogenase complex, which is a critical step in aerobic respiration.


Which of the following correctly matches the phase of cellular respiration with its location in the cell?

Pyruvate dehydrogenase complex . . . mitochondrial matrix


Can pyruvate cross the mitochondrial membrane?

Yes, pyruvate can cross the mitochondrial membrane through specific transport proteins.


What happen before acetyl CoA can be formed during respiration?

Before acetyl CoA can be formed during respiration, glucose is broken down through glycolysis to produce pyruvate. Pyruvate is then converted to acetyl CoA in the mitochondrial matrix by the enzyme pyruvate dehydrogenase complex. This process generates NADH and CO2 as byproducts.


Where is pyruvate metabolized?

pyruvate is converted into acetyl coA in the mitochondrial matrix


What process transport pyruvic acid across the mitochondrial membrane from a high concentration to low concentration?

Pyruvic acid is transported into the mitochondria through a carrier protein known as the mitochondrial pyruvate carrier (MPC). The MPC uses the energy stored in the proton gradient across the mitochondrial membrane to move pyruvate against its concentration gradient. This process helps maintain the flow of pyruvate from the cytoplasm into the mitochondria for further energy production through aerobic respiration.


What are the stages of aerobic respiration in the correct order and where do they take place in the cell AND how many ATP are made in each?

The stages of aerobic respiration are glycolysis (cytoplasm: 2 ATP), pyruvate oxidation (mitochondrial matrix: 0 ATP directly produced), the citric acid cycle (mitochondrial matrix: 2 ATP), and oxidative phosphorylation (inner mitochondrial membrane: approximately 28-34 ATP).


What has to be present for Pyruvate to enter the mitochondria?

The mitochondrial membrane has special transporter proteins which are needed to transport pyruvate. This transport also requires ATP.


Does pyruvate diffuse into the mitochondria for cellular respiration?

Yes, pyruvate does diffuse into the mitochondria for cellular respiration.


What are the 4 main stages of cellular respiration and where do they take place in a eukaryotic cell?

The 4 main stages of cellular respiration are glycolysis (in the cytoplasm), pyruvate oxidation (in the mitochondria), the citric acid cycle or Krebs cycle (in the mitochondria), and oxidative phosphorylation (in the inner mitochondrial membrane).


Glycolysis produces pyruvate. The fate of this pyruvate depends mainly on the availability of which of the following?

Molecular oxygen


Acetyl CoA accumulates where in cellular respiration?

Acetyl CoA accumulates in the mitochondrial matrix as a result of the conversion of pyruvate via pyruvate dehydrogenase complex in the transition reaction during cellular respiration. It serves as the starting point for the citric acid cycle, where it undergoes further oxidation to release energy.