What is the genetic basis for neuroses and psychoses?

Answer 1

Traditionally mental disorders are categorised into minor or neuroses and major or psychoses. This appears to be false. There is no 'quantitative' difference between these two. The difference is most probably 'qualitative'. So psychoses are probably genetic and has a strong hereditary element in them. Almost 50 % population is suffering from it. So there is spectrum of psychoses from say 1 to 99 %. They probably have some different neurotransmitters in the brain. So many patients of minor degree of psycoses go unidentified and treated like patients of neuroses. With out much satisfactory results. Such patents are given tablet prochlorperazine 5 to 10 mg at bed time along with benzodiazepines like diazepam 5 to 10 mg. They respond very well to it. This drug belong to the phenothiazine group. This is used wide spread for treatment of vomiting syndrome. If you give 5 or 10 mg of chlorpromazine, then chemist will only tell the patient that this is the drug for mental illness and patient will not take it. So in the guise of antiemetic, you can safely use the prochorperazine tabs, as a low dose antipsychotic and this has been never noted by chemist and other doctors too. This is been used in large number of patients with satisfactory results. If you need more dose then oleanzapine 2.5 mg at bed time can be given or 5 mg at bed time. In neuroses you can always identify the tragedy responsible for the anxiety or depression in case of the patient. Or there may multiple small such incidences. If in doubt, you can give a therapeutic trial and find out the category in which patient belongs to. So this old classification of neuroses and psychoses probably needs revision.

Answer 2

Neuroses and psychoses are complex mental health conditions influenced by a combination of genetic, environmental, and social factors. Although specific genes that contribute to neuroses and psychoses have not been definitively identified, research suggests a polygenic inheritance pattern, where multiple genes interact with environmental factors to increase susceptibility. Neurotransmitter dysfunction and brain structure abnormalities have also been implicated in the development of these conditions.