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It depends on many factors, and there is a great deal of variability in the syndrome and the health problems associated with it.

This report is probably the best compilation on the subject. It is available in the Literature section of http://clsf.info.

Coffin-Lowry Syndrome: A 20-Year Follow-Up and Review of Long-Term Outcomes American Journal of Medical Genetics111:345-355 (2002)

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Coffin-Lowry Syndrome Foundation

i think it only matters on the the person and what the person has specifically

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