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Mammalian cells need a lot of energy, so they must have a continual supply of oxygen for respiration. Oxygen is not very soluble in plasma; 100ml off blood could only carry 0.2 ml of oxygen if it relied on oxygen being dissolved in the plasma. Haemoglobin (found in red blood cells) contains four active sites where oxygen molecules can be attached. Haemoglobin molecules increase the oxygen-carrying capacity of blood by 100 times, to about 20ml of oxygen in 100ml of blood.

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