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A protein that has a helix-turn-heloix domain can bind to DNA because one of the helices interacts with the sugar phosphate backbone of a DNA strand while the other helix binds to the base bairs in the major groove. The section of the helix-turn-helix motif that binds inside the major groove is called the "recognition sequence"

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βˆ™ 15y ago
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βˆ™ 5mo ago

The helix-turn-helix motif is responsible for recognizing specific DNA sequences in the major groove for both CAP and lac repressor. This motif consists of two alpha helices separated by a short loop, with the second helix directly interacting with the DNA bases.

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Q: What part of CAP and lac repressor are directly responsible for recongnition of specific DNA sequences in the major groove?
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