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A nonsense mutation is a genetic mutation in a DNA sequence that leads to the appearance of a stop codon where previously there was a codon specifying an amino acid. DNA is a chain of many smaller molecules called nucleotides. During protein formation, DNA (or RNA) nucleotide sequences are read three nucleotides at a time in units called codons, and each codon corresponds to a specific amino acid or stop codon, which is also called nonsense codon because it does not code for an amino acid and instead signals the end of protein synthesis. Therefore, nonsense mutations occur when a premature nonsense or stop codon is introduced in the DNA sequence. When the mutated sequence is translated into a protein, this premature stop codon results in the production of a shortened, and likely nonfunctional, protein.

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Jaycee Emard

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Related Questions

What mutation causes the DNA replication to stop early?

Nonsense


What are the types of mutations that can occur?

nonsense mutation, missense mutation, frameshift muation, deletion or addition mutation


What are the similarities of a nonsense mutation and a missense mutation?

Both nonsense and missense mutations are point mutations - meaning a single base has been substituted. The difference between the two is that a missense mutation results in an amino acid being replaced with a different amino acid, whereas a nonsense mutation results in a premature stop codon.


A point mutation that changes a codon specifying an amino acid into a stop codon is called a?

nonsense mutation


What kind of mutation will result from the mistake made during DNA replication in the nucleotide sequence?

a nonsense mutation


What mutation stops translation of the mRNA?

The type of mutation that stops the translation of a protein is a nonsense mutation. This occurs when a base substitution (point mutation) results in a STOP codon and thus stops translation of the sequence into a protein.


A mutation that causes antibiotic resistance in bacteria is a what mutation?

Missense mutation Nonsense mutation Frameshift insertion Frameshift deletion All may cause antibiotic resistance in bacteria


What is the difference between a nonsense mutation and a missense mutation?

Missense mutation: changes one sense codon to another, resulting in incorporation of amino acid.Nonsense mutation: changes a sense codon into a stop (or nonsense) codon, resulting in premature termination.


A genetic mutation that causes a codon that should code for a specific amino acid to be changed into a stop codon results in a shortened protein product and is known as?

A premature stop codon mutation, also known as a nonsense mutation. This mutation causes the translation of the protein to be halted prematurely, leading to a truncated and often nonfunctional protein product.


A change in the sequence of DNA that results in a protein that is too short?

Nonsense mutation


What type of mutation will affect the largest number of proteins produces by an organism?

Chromosomal mutation


Will a point mutation cause the cell to make an incomplete polypeptide if the mutation results in a stop codon?

Yes, a point mutation will cause the cell to make an incompelete polypeptide chain that is non-functional, if the mutation results in a stop codon. This type of a mutation is also called as the Nonsense Mutation.

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