What type of mutation affects the largest number of genes?

Answer 1

Chromosomal mutation

Answer 2

Chromosomal mutation

Answer 3

This question is a tough one, given that the cell of any organism can respond to dysfunction (mutation) in unpredictable ways. Also, mutations that affect a large number of unique proteins will be quite different from mutations that affect many copies of a single protein (i.e. your cell has a ton of actin, a structural protein, and a mutation in just that one protein will be devastating.)

Now with the caveats out of the way, several candidates for wide ranging disruption immediately emerge. If you want to disrupt/affect a cell's protein production you would probably want to aim for protein synthesis machinery that is universal to all proteins. A critical mutation in universal transcriptional machinery (RNA polymerase), translational machinery (proteins that make up the ribosome), or post-translational machinery (proteins responsible for proper folding and degradation, like those that make up the proteasome, or the E1 ubiquitin activating enzyme) would affect a tremendous number of proteins and would probably be lethal to the organism.

Answer 4

A frameshift mutation is a type of mutation involving the insertion or deletion of a nucleotide in which the number of deleted base pairs is not divisible by three. Each group of three bases (codons) corresponds to one of 20 different amino acids used to build a protein.

If a mutation disrupts this reading frame, then the entire DNA sequence following the mutation will be read incorrectly.

Here is an example of one sentence with words of only three letters: The big red pig ate the red rag. Each word will make one amino acid and the words make a sentence that makes sense.

This type might make the sentence totally readable: The big res dpi gat eth ere dra g.

Answer 5

According to the National Human Genome Institute, most all disease have some sort of genetic factor. These disorders can be caused by a mutation in a single gene, multiple gene mutations, combined gene mutation and environmental factors, or by chromosome mutation or damage.

Mutations can occur in which nucleotide base pairs are inserted into or deleted from the original gene sequence.
This type of gene mutation is dangerous because it alters the template from which amino acids are read. Insertions and deletions can cause frame shift mutations when base pairs that are not a multiple of three are added to or deleted from the sequence. This type is affects the largest number of genes.

Answer 6

Chromosomal mutations, such as deletions or duplications, can affect multiple genes at once because they involve changes in the structure or number of chromosomes. These mutations can impact large regions of genetic material, influencing the expression of many genes simultaneously.

Answer 7

Chromosomal mutation (Apex)

Answer 8

Chromosomal