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Different atoms, particularly carbon, hydrogen, nitrogen and oxygen, made up molecules into such things as proteins, lipids, phospholipids, enzymes, and amino acids. These molecules are part of what makes up a cell, including DNA, and is obviously the first "material" that was first seen in cells.
Cells are made/constructed of many different chemicals, but when were they first seen? In the 1670's, Anton van Leeuwenhoek saw microscopic organisms with a microscope that he had fashioned... but there could have been someone who saw them before that... certainly people who knew of their existence.

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