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If the Watson-Crick model of DNA had been inconsistent with Chargaff's rule, it would have indicated a fundamental flaw in our understanding of DNA structure and function. Chargaff's rule states that the amount of adenine should be equal to the amount of thymine, and the amount of guanine should be equal to the amount of cytosine in a DNA molecule. This consistency is critical for the stability and replication of DNA.

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