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Eukaryotic Linear Motif resource was created in 2011.

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Q: When was Eukaryotic Linear Motif resource created?
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What are the major problems requiring the use of supercomputing in the following domains structural mechanics computational biology commercial applications?

Computational Biology:Network motif problem


What part of CAP and lac repressor are directly responsible for recongnition of specific DNA sequences in the major groove?

A protein that has a helix-turn-heloix domain can bind to DNA because one of the helices interacts with the sugar phosphate backbone of a DNA strand while the other helix binds to the base bairs in the major groove. The section of the helix-turn-helix motif that binds inside the major groove is called the "recognition sequence"


Properties of fibrous and globular proteins?

Fibrous proteins are formed from the folding of beta pleated sheets and have a secondary, tertiary and quaternary structure. Globular proteins are formed from the coiling of alpha helices and have a tertiary and quaternary structure.I hope that helps!!!


What is the function of receptor proteins?

Receptor proteins are designed so special molecules can bind to them, and send messages to the cell that trigger some sort of reaction within the cell.They are embedded in either the plasma membrane or cytoplasm of a cell, to which a mobile signaling (or "signal") molecule may attach.Sources: http://en.wikipedia.org/wiki/Receptor_proteins


How do proteins recognize and bind to DNA?

In simple terms proteins have specific structures to bind DNA, these have specific Amino Acids that give specificity for certain DNA sequences. As far as I am aware the main binding force is Hydrogen bonds between the Amino Acids and the DNA bases. More specifically there are three well known of DNA binding motifs that proteins have. These are: Homeodomains (Helix-Turn-Helix) This class has three alpha helices, the 3 helix sits in the major groove of DNA and interacts with it in a base specific manor via Hydrogen bonding. Helix 1 and 2 sit above the DNA strand to stabilise the binding and the N terminal tail interacts in the minor groove. Zinc Fingers Form a special structure around a zinc atom (held by interaction with Cysteine and Histidine residues) to stabilise them (the protein motif is too small to have a hydrophobic core). To bind DNA the alpha helix (where the Histidine residues are found) of the domain again typically iteracts with the major groove of the target DNA. Basic Leucine Zippers These consist of two long alpha helices bound together by interactions between leucine residues found every 7 amino acids on each chain. The ends of the helices have a basic region that is responsible for binding DNA, again in the major groove. That is all I can remember off the top of my head, hope it helps.