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All T cells originate from hematopoietic stem cells in the bone marrow. Hematopoietic progenitors derived from hematopoietic stem cells populate the thymus and expand by cell division to generate a large population of immature thymocytes. The thymus is an organ located in the upper anterior position of the chest cavity just behind the sternum. The main function of the thymus is to provide an area for T lymphocyte maturation.

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