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There had been theories that there were infectious agents smaller than bacteria but it had not been proven until the first plant virus was discovered in 1898, tobacco mosaic virus, by the Martinus Beijerinck.

The experiments continued, and animal viruses, as well as plant viruses, were grown in labs on eggs and animal tissues by several scientists. Cow pox was one of the early animal viruses isolated. Then in 1913, E. Steinhardt, C. Israeli and R. A. Lambert were able to isolate and grow the vaccinia virus, a virus that was a human poxvirus. This was the first virus used to create a vaccine and was how small pox was eradicated (the first human disease that scientists were able to eliminate). Vaccines and vaccinations get their names from this work with the vaccinia virus. It was an extension of their work that also enabled the vaccines for poliovirus to be developed in the 1950's. The first time a human virus was actually seen, was when electron microscopy was invented and used in 1931 by two German engineers, Ernst Ruska and Max Knoll, to make the first ever images of viruses.

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16y ago

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