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Why depyrimidination doesnot occur?

Updated: 4/28/2022
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14y ago

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I'm still looking for a good answer to this one. I've actually read that it does occur but at a much slower frequency than depurination. Apparently, the depyrimidination frequency is around 500 pyrimidines per cell per day as opposed to 10,000 depurinations per cell per day. It seems counterintuitive really, when you think of the steric hindrance the water would encounter when attacking the glycosidic bond of a large purine double ring vs. the same force experienced near the smaller pyrimidine single ring.

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14y ago
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Q: Why depyrimidination doesnot occur?
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