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Short and simple: This position allows the flow of solution by gravity into the sigmoid colon and rectum.

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Q: Why enema is given in left lateral position?
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Best position to take the enema?

Depends on what is comfortable for you I recommend for comfort Is laying on your left side with your knees drawn up to your chest. Or you can lay flat on your bag with a pillow under your hips to make the enema flow more into your colon and work more. Alternatively you can go on all fours and have you bum in the air and your head near the floor and let gravity do it's job.