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The most common type of ALD (adrenoleukodystrophy) is X-linked ALD. Than means that the gene for ALD is on the X chromosome.

Because boys have only one X chromosome, if it has the ALD gene on it they will have the disease.

Girls have two X chromosomes, so, in order to get ALD both of their X chromosomes would have to have an ALD gene. That would mean that both her father and her mother would have to have an ALD gene. Because males with ALD die before they can have children this would not happen. So girls don't get this type of ALD.

There are other, more rare types of ALD that affect both boys and girls. So, all in all, fewer girls have ALD

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Q: Why is a disease like ALD much more common in boys than in girls?
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