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Bone is considered anisotropic because it responds differently if forces are applied in different directions. Bone can handle large forces applied in the longitudinal plane (tension and compression); bone is not as strong in handling forces applied transversely across its surface.
The differences between the properties of the cancellous and cortical bone contribute to the anisotropy of the bone. Cancellous bone provides bending strength, and cortical bone provides significant compressive strength.

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