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Colchicine is a drug that prevents tubulin polymerisation into cytoskeleton structures called microtubules. Microtubules are essential for many functions of the cell, but importantly are needed for cell division. Specifically, they help align homologous chromosomes on the metaphase plate during metaphase and then separate the chromosome pairs during anaphase. So by inhibiting the production of microtubules, the chromosomes never align on the metaphase plate - they will be fully condensed but spread throughout the cell, a situation called a metaphase spread
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What is the chemical that stops cell division in the metaphase stage?
colchicine is used to stop cell cycle during metaphase. In chromosome karyotype analysis, it is used.
What phase of meiosis is photographed when creating a karyotype?
The optimal phase is metaphase, since during metaphase all sister chromatids are paired and lined up neatly at the centre of te cell. A solution of colchicine is usually used to arrest dividing cells at metaphase so that a picture can be taken.
When during mitosis are karyotypes made?
Cells in metaphase are used to produce karyotypes.
What is the natural source of colchicine?
According the the Centers for Disease Control, "Colchicine, a naturally occurring alkaloid derivative of the autumn crocus Colchicum autumnale and the glory lily Gloriosa superba, has been used to treat gout for centuries." -- http://www.cdc.gov/mmwR/preview/mmwrhtml/mm5640a3.htmThe crocus is mentioned on numerous alternative medicine sites as well.
What is colchicines?
Colchicine is a prescribed drug or medication used in the treatment of gout. Patients take this medication to prevent gout attacks that present symptoms like joint pain in toes. The symptoms of gout occur when there is a buildup of uric acid in the blood.
What is the chemical that stops cell division in the metaphase stage?
colchicine is used to stop cell cycle during metaphase. In chromosome karyotype analysis, it is used.
What phase of meiosis is photographed when creating a karyotype?
The optimal phase is metaphase, since during metaphase all sister chromatids are paired and lined up neatly at the centre of te cell. A solution of colchicine is usually used to arrest dividing cells at metaphase so that a picture can be taken.
What are colchicine tablets used for?
Colchicine is a drug used in the treatment of acute gouty arthritis. Colchicine is effective in suppressing the inflammation in acute gouty arthritis.
Why is colchisine used in karyotypic determination?
Colchicine causes microtubules to depolymerise. During cell division at the metaphase stage condensed chromosomes line up and are then pulled apart to either pole by microtubules. Hence adding colchicine to a cell culture stops cells completing mitosis. This is useful as a means of accumulating metaphases in the culture before harvesting. Typically colchicine (or the less toxic colcemid) is added about 30mins to 1 hour before harvesting, varying depending on cell type, species etc.
When during mitosis are karyotypes made?
Cells in metaphase are used to produce karyotypes.
Is colchicine a form of NSAID?
Yes, colchicine is a form of NSAID. It is used as an anti-inflammatory and pain reliever in the treatment of rheumatic and arthritic pain also in the case of gout it is often used as a prophylactic drug.
Why is colchicine a drug in gouty arthritis?
Colchicine is used to treat acute gouty arthritis. When is severe inflammation as a resut of uric acid crystals forming in the synovial joints, causing severe pain, redness, and swelling in the affected joint(s). Colchicine iis used to suppress the inflammation. the precise reason for the action of colchicine is still unknown. it could cause reduction in uric acid deposition in turn leading to a reduction in the inflammatory response. Colchicine is not an analgesic (pain killer), but it does reduce pain in acute gouty arthritis.
What are the phases present in mitosis?
Interphase (commonly not used but still important to mitosis), prophase, prometaphase (sometimes not used, but in higher education it is used because metaphase is so long), metaphase, anaphase, telophase/cytokinesis.
What substance is used to arrest a cell in metaphase for karyotype preparation?
Colchicines
Is glucose used while preparing liquors?
while preparing liquors what is not added
What is the world's dangerous flower?
One of the most endangered plants in the world, Autumn crocus is also probably the most poisonous. It contains colchicine, a deadly drug used effectively in the treatmentfor gout. Unlike other toxins found in the flowers above, colchicine, an arsenic-like poison has no antidote.
How the gerund is used in I helped by preparing dinner?
In this sentence "preparing dinner" is the gerund phrase. A gerund is a verb doing the job of a noun. Preparing is the gerund form of the verb prepare.
