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When making esters, it's important to work in a well-ventilated area or under a fume hood to avoid inhaling harmful vapors. Always wear appropriate personal protective equipment, including gloves, goggles, and a lab coat, to protect against chemical spills and splashes. Use caution when handling strong acids or bases, which are often involved in the esterification process, and have a neutralizing agent and safety shower accessible in case of spills. Additionally, ensure that all glassware is properly secured and heated gently to prevent breakage or splattering.

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