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An enzyme citrate synthase in the Krebs cycle is inhibited by ATP What type of inhibition would this be?
Wiki User
∙ 15y ago
Citrate synthase is inhibited by ATP. Obviously, the Krebs cycle produces ATP. This is the first step and one of the major regulatory steps in the pathway. If the cell has plenty of ATP, then it wouldn't need to keep making it, thus the pathway needs to be shut off. ATP inhibits the enzyme to shut off the pathway. This is an example of feedback inhibition (you can also call it negative inhibition or even product inhibition). Feedback inhibition is when the products of a certain biochemical pathway inhibit earlier enzymes, shutting down the pathway.
Wiki User
∙ 15y ago
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What is inhibition and why enzymes need to be inhibited?
- Inhibition of an enzyme is to inhibit the catalytic activity of the enzyme. - Because, by blocking or inhibiting an enzyme's activity can kill a pathogen or correct a metabolic imbalance. Example : Inhibition of HIV protease.
What molecules initiate the citric acid cycle by reacting with oxaloacetate?
Oxaloacetate [oxaloacetic acid], under the strict guidance of the enzyme 'citrate synthase', is reacted with the co-enzyme 'Acetyl-CoA' to form the products CoA and citric acid.
What happens if an inhibitor is irreversible?
Irreversible inhibition refers to the inactivation of an enzyme by a tightly, typically covalent, bound inhibitor. The kinetics for irreversible inhibition do not follow competitive or non-competitive kinetics.
What is an enzyme that is blocked?
Inhibited. Competitive, noncompetitive, allosterically and so on.
What is the rate limiting enzyme of the urea cycle?
it is Carbamoyl phosphate synthase 1 which does the following:CO2 & NH3 -> Carbamoyl phosphatedon't forget the rate limiting enzyme is stimulated by N-acetylglutamate (NAG)
What happens when a protein is inhibited?
When a enzyme is inhibited (many proteins are enzymes), it just means that the enzyme will be reduced in its ability to catalyze a reaction. There are a few types of Inhibition like Competitive Inhibition, Noncompetitive Inhibition, and Irreversible Inhibition.
What is inhibition and why enzymes need to be inhibited?
- Inhibition of an enzyme is to inhibit the catalytic activity of the enzyme. - Because, by blocking or inhibiting an enzyme's activity can kill a pathogen or correct a metabolic imbalance. Example : Inhibition of HIV protease.
What compound is produced by the transfer of the acetyl group of acetyl CoA to oxaloacetate?
Citric acid or citrate. The reaction is catalyzed by the citrate synthase enzyme.
How are citric acid produced?
A Condensation reaction between oxaloacetate and acetyl CoA by the enzyme citrate synthase
When does enzyme inhibition occur?
Your body is full of enzymes that do various things for you. They aid in performing chemical reactions. But, if you put something in your body (like a drug or toxin), the enzymes can get messed up and not work. So, enzyme inhibition means that an enzyme is being inhibited (messed up) by something.
What are the two types of Feedback Inhibition?
In my understanding there are three types of feedback inhibition:SIMPLE: Enzyme inhibited by single end product.CUMULATIVE: More than one end product inhibits the same enzyme. That means that each product exerts partial inhibition and inhibition is cumulative.CONCERTED: More than one end product must bind the same enzyme simultaneously for any inhibition.I !
What is the coenzyme that transports organic molecules into the citric acid cycle?
Acetyl-coenzyme A: catalyzed by the enzyme 'Citrate Synthase'. Two carbons are transported each time.
What molecules initiate the citric acid cycle by reacting with oxaloacetate?
Oxaloacetate [oxaloacetic acid], under the strict guidance of the enzyme 'citrate synthase', is reacted with the co-enzyme 'Acetyl-CoA' to form the products CoA and citric acid.
How is glycolysis turned off?
When an enzyme in a pathway is inhibited by the product of the reaction sequence, feedback inhibition occurs. The product molecule "feeds back" to stop the reaction sequence when the product is abundant.
What happens if an inhibitor is irreversible?
Irreversible inhibition refers to the inactivation of an enzyme by a tightly, typically covalent, bound inhibitor. The kinetics for irreversible inhibition do not follow competitive or non-competitive kinetics.
What is feedback inhibition?
A cellular control mechanism in which an enzyme that catalyzes the production of a particular substance in the cell is inhibited when that substance has accumulated to a certain level, thereby balancing the amount provided with the amount needed.
What does citrate permease do?
Citrate Permease is an enzyme that is responsible for transporting citrate inside the cell. Some bacteria have this enzyme while others do not. You can test for the presence of citrate permease by performing a Simmon's Citrate biochemical test.
