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Regardless of whether or not one has heart problems, nitroglycerin (NTG) relaxes smooth muscle. This is most important in blood vessels, where it enlarges arteries and veins, improving circulation and lowering blood pressure.

Its most common medical use is for angina pectoris (discomfort, often in the chest, or breathing problems due to inadequate circulation to the heart muscle), but it's also effective for esophageal spasm.

If too much NTG is taken in a short period, particularly if one is not used to it, the BP can be dangerously lowered, reducing circulation and possibly causing fainting or other serious problems. Fortunately NTG's half-life is just 5-10 minutes, so it wears off rapidly in case of overdose.

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