How might a polar medicine behave differently within your body than a nonpolar medicine would?

Answer 1

The compounds in medicine should be non polar.

• It is important for any drug to be able to dissolve itself through the cell membrane which consists of a lipid bi-layer, in order to diffuse in the body and circulate biologically, performing its function.
• Non polar compounds are lipid soluble and therefore can dissolve in the lipid layers.
• Polar compounds are water soluble and fail to cross the cell membrane.
• Therefore scientists need to be sure of using compounds that are non polar in nature so they pass through the cell membrane and enter into the blood circulation of the body and perform its due function.

Answer 2

Polar medicines are water-soluble and tend to distribute more in body fluids like blood, while nonpolar medicines are fat-soluble and may accumulate in fatty tissues. This can affect their distribution, metabolism, and excretion in the body. Polar medicines may be excreted more easily in urine, while nonpolar medicines may be metabolized in the liver and excreted in bile.