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Cyanide is an Electron transport inhibitor, effective reversible inhibitor of cytochrome oxidase, inhibit oxygen consumption by mitochondria.

Oxygen is utilized for the production of essential cellular energy sources in the form of ATP (adenosine triphosphate). Importnat part of this process is transfer of electrons from NADH (nicotinamide adenine dinucleotide, supplied via the Kreb's Cycle) to oxygen. This is catalyzed by the cytochrome oxidase enzyme system in the mitochondria, and the rupture arises from the inhibition by cyanide of cytochrome oxidase. Other metabolic processes continue and the rate of glycolysis is increased markedly; however the pyruvate so produced can no longer be utilized via the impaired Kreb's Cycle, and is reduced to lactate, resulting in a metabolic acidosis. Cyanide significantly decreases brain ATP and increases brain lactate levels.

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11y ago

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