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refer ICH chapter Q2(R1) for beter underrstsnding.

Dnyaneshwar Patil

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12y ago

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What is the difference between LOD and Moisture Content?

MC gives only % of water in a substance(Low melting range substance).But LOD result is a combination of water content and other volatile organic solvents.And more over Melting range of a substance has to be considered in case of LOD. Substances whichever is having high melting point is required for LOD checking.


How do you calculate the limit of detection from a calibration curve?

The limit of detection (LOD) can be calculated as 3 times the standard deviation of the y-intercept divided by the slope of the calibration curve. This value represents the smallest concentration of analyte that can be reliably measured with the method.


What Loss on drying formula for solid powder forms?

The Loss on Drying (LOD) formula for solid powder forms is typically calculated as: LOD (%) = ((Initial weight - Final weight) / Initial weight) x 100 Where: Initial weight is the weight of the sample before drying. Final weight is the weight of the sample after drying.


What is the difference between Karl fisher and loss on drying?

Karl Fischer titration is a method for determining water content in a sample by using a titrant that reacts specifically with water. Loss on drying (LOD) is a technique that involves heating a sample to evaporate volatile components, such as water, and measuring the weight loss as a percentage of the initial sample weight. Karl Fischer is more precise and specific for water determination, while LOD is a general method that can include other volatile substances as well.


What are the substances that are soluble in water?

For example, if you had salt (solid) in water, that would be a soluteDissolved water is a Solvent= Salt water Solutionhope this helps, please recommend :)