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How do you synthesize methaqualone?

Updated: 8/10/2023
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Wiki User

15y ago

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7g Anthranilic Acid, 5ml o-Toluidine and 4 ml glacial acetic acid was mixed in a round-bottomed flask. To this mixture was slowly added 40-50 grams of polyphosphoric acid, and the mixture was heated during 20-30 minutes to 140-160°C. After this, the mixture was heated to 180°C for 10 minutes, then cooled and poured in 150-200ml water, and neutralized with 20% Na2CO3 solution. Methanol was added until a lasting turbidity became present in the solution, and after one hour, the free base Methaqualone precipitated, mp 111-113°C, and was once more recrystallized in this fashion, mp 113-115°C. Yield 55%.

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15y ago
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16y ago

Since there are several accepted methods, It is likely you have no idea what you are asking.

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Wiki User

12y ago

with iron

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Q: How do you synthesize methaqualone?
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