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In theory, just one. Methamphetamine is one chemical. In application, a lot. Most meth is not manufactured in legitimate laboratories, so there's risk of contamination with the chemicals used to make it - nasty chemicals like Sodium Hydroxide and Hydroiodic acid. Then, once it's made it out of someone's basement, it's likely to be cut - mixed in with some other substance by the dealer, so that he can sell 20 grams of cut meth instead of 10 grams of pure meth. There's no telling what gets put in it here - but a few common adulterants are baby powder, baking soda, and over the counter laxatives. Some dealers have even cut their meth with rat poison before selling it.

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