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How might an amino acid change at a site distant from the active site of the enzyme alter the enzyme's substrate specificity?
Wiki User
∙ 12y ago
The alteration of an amino acid on a site other than the active site will: change the shape of the protein.
Wiki User
∙ 12y ago
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Inhibitors of enzymes-catalyzed reactions act by?
Different Enzymes inhibit in different ways. Some are structural analogue of substrate and they compete the substrate in binding to the enzyme. Some inhibitors bind in the active site and prevent the binding of the enzyme. Some enzymes doesn't bind the active site but they change the active site properties that prevent the efficient binding of the substrate. some time substrate in large quantity may inhibit the enzyme, while other times the product formed may do so.
What causes enzymes to be different from one another?
Enzymes are a type of protein and are thus formed by ribosomes - every protein exits the ribosome as a linear strand. It is this 'primary sequence' of amino acids that is different in each protein and empowers each enzyme with its own unique function.
What is enzyme-substrate specificity?
It means that an enzyme will only work on one specific substrate at a time, because no meaningful biochemical activity can occur without their absolute specificity.We are talking about 30,000 bio-enzymatically controlled Biochemical reactions.In the Chem Lab a product yield of 60 percent is a huge achievement.In the Body anything less than a 100 percent yieldwould swiftly result in the Cell being overwhelmed by the useless by-products of these 30,000 biochemical Reactions.
The difference between substrate and active site?
substrate goes in the active site. so if you have an ezyme, there would be a region where the substrate would fit into the active site.
What is the meant by the lock and key hypothesis?
The lock is the equivalent to that of an enzyme while the key is portrayed as the substrate. Like an enzyme, the lock can be reused many times as it remains chemically unchanged at the end of the reaction. Also, the fact that reactions occur only at the active site, or binding site, is showed as the key only being able to open the lock only at the keyhole, not anywhere else. The hypothesis also shows the fact that enzymes can only catalyse a specific substrate, showed as the lock, only being able to open with a specific key. Firstly,the substrate will enter the active side of the enzyme.then,the enzyme will change it shape slightly as the substrate binds.During this time,the substrate will be broken down.After that,the product will leave the active sides of the enzyme.
What would be unlikely to contribute to the substrate specificity of an enzyme?
The allosteric site is distinct from the active site, and does not affect the substrate specificity of the enzyme
How does an enzymes active relate to its substrate?
The substrate binds to the active site.
How does an enzymes active site relate to it substrate?
The substrate binds to the active site.
How does an enzymes active site relate to its substrate?
The substrate binds to the active site.
How does an enzymes active site relate to it's substrate?
The substrate binds to the active site.
Substrate molecules bind to enzymes where?
The bind in the active site.
The specificity of an enzyme is due to its active siteThe active site is a shape only a certain?
An enzyme's active site will bind with only a specific substrate. Any other kind of substrate will be rejected by the active site.
How does an enzymes activate site relate to its substrate?
The substrate binds to the active site.
What happens if enzymes loose their specificityAsk us anything?
They can't catalyse reactions. The specificity of the active site of the enzyme is crucial: without it, the enzyme won't fit with he desired substrate, hence there won't be any reaction. Losing this specificity is due to a conformational change at the active site, andis known as denaturisation.
Why must a molecule have a specific shape if it is to be a substrate of an enzyme?
Active sites of enzymes (where the substrates fit in) are substrate specific, and are complementary to the shape of the molecule (substrate). In this way, enzymes can only act on a specific substrate, since that is the only shape that it will accommodate in the active site.
How enzyme structure makes an enzyme very specific?
Enzymes are proteins, which are made up of amino acids. Each enzyme has a different sequence of amino acids and changing even one amino acid will mean that the tertiary structure of the enzyme will be lost and so will it's active site. As enzymes are substrate specific, only a certain substrate will bind to its active site, due to its amino acid sequence determining the shape of the active site.
Why do enzymes generally bind to only type of substrate?
Enzymes act only on a specific substrate due to the active site of the enzymes fits perfectly with the substrate. Like 2 puzzle pieces, they can only go together and not with anything else.
